Association of high viral load and abnormal liver function with high aflatoxin B1-albumin adduct levels in HIV-positive Ghanaians: preliminary observations
Identifieur interne : 000903 ( Main/Exploration ); précédent : 000902; suivant : 000904Association of high viral load and abnormal liver function with high aflatoxin B1-albumin adduct levels in HIV-positive Ghanaians: preliminary observations
Auteurs : P. E. Jolly [États-Unis] ; F. M. Shuaib [États-Unis] ; Y. Jiang [États-Unis] ; P. Preko [Ghana] ; J. Baidoo [Ghana] ; J. K. Stiles [États-Unis] ; J.-S. Wang [États-Unis] ; T. D. Phillips [États-Unis] ; J. H. Williams [États-Unis]Source :
- Food additives & contaminants : part A chemistry, analysis, control, exposure & risk assessment
Descripteurs français
- Pascal (Inist)
- Wicri :
- geographic : Ghana.
- topic : Association.
English descriptors
- KwdEn :
- Adduct, Aflatoxin B1, Albumin, Association, Ghana, Liver, Virus.
Abstract
We examined the association between certain clinical factors and aflatoxin B1-albumin adduct (AF-ALB) levels in HIV-positive people. Plasma samples collected from 314 (155 HIV-positive and 159 HIV-negative) people were tested for AF-ALB levels, viral load, CD4+ T-cell count, liver function profile, malaria parasitaemia, and hepatitis B and C virus infections. HIV-positive participants were divided into high and low groups based on their median AF-ALB of 0.93 pmol mg-1 albumin and multivariable logistic and linear regression methods used to assess relationships between clinical conditions and AF-ALB levels. Multivariable logistic regression showed statistically significant increased odds of having higher HIV viral loads (OR=2.84; 95% CI=1.17-7.78) and higher direct bilirubin levels (OR=5.47; 95% CI=1.03-22.85) among HIV-positive participants in the high AF-ALB group. There were also higher levels of total bilirubin and lower levels of albumin in association with high AF-ALB. Thus, aflatoxin exposure may contribute to high viral loads and abnormal liver function in HIV-positive people and so promote disease progression.
Affiliations:
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Shuaib</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Epidemiology, University of Alabama at Birmingham</s1><s2>Birmingham, AL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Jiang, Y" sort="Jiang, Y" uniqKey="Jiang Y" first="Y." last="Jiang">Y. Jiang</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Epidemiology, University of Alabama at Birmingham</s1><s2>Birmingham, AL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Preko, P" sort="Preko, P" uniqKey="Preko P" first="P." last="Preko">P. 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Williams</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>College of Agricultural and Environmental Sciences, University of Georgia</s1><s2>Griffin, GA</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0451417</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0451417 INIST</idno><idno type="RBID">Pascal:11-0451417</idno><idno type="wicri:Area/PascalFrancis/Corpus">000029</idno><idno type="wicri:Area/PascalFrancis/Curation">000103</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000028</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000028</idno><idno type="wicri:Area/Main/Merge">000906</idno><idno type="wicri:Area/Main/Curation">000903</idno><idno type="wicri:Area/Main/Exploration">000903</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Association of high viral load and abnormal liver function with high aflatoxin B<sub>1</sub>-albumin adduct levels in HIV-positive Ghanaians: preliminary observations</title><author><name sortKey="Jolly, P E" sort="Jolly, P E" uniqKey="Jolly P" first="P. E" last="Jolly">P. E. Jolly</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Epidemiology, University of Alabama at Birmingham</s1><s2>Birmingham, AL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Shuaib, F M" sort="Shuaib, F M" uniqKey="Shuaib F" first="F. M" last="Shuaib">F. M. Shuaib</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Epidemiology, University of Alabama at Birmingham</s1><s2>Birmingham, AL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Jiang, Y" sort="Jiang, Y" uniqKey="Jiang Y" first="Y." last="Jiang">Y. Jiang</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Epidemiology, University of Alabama at Birmingham</s1><s2>Birmingham, AL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Preko, P" sort="Preko, P" uniqKey="Preko P" first="P." last="Preko">P. Preko</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>AIDS ALLY and St. Markus Hospital</s1><s2>Kumasi</s2><s3>GHA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Ghana</country><wicri:noRegion>AIDS ALLY and St. Markus Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Baidoo, J" sort="Baidoo, J" uniqKey="Baidoo J" first="J." last="Baidoo">J. Baidoo</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>AIDS ALLY and St. Markus Hospital</s1><s2>Kumasi</s2><s3>GHA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Ghana</country><wicri:noRegion>AIDS ALLY and St. Markus Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Stiles, J K" sort="Stiles, J K" uniqKey="Stiles J" first="J. K." last="Stiles">J. K. Stiles</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine</s1><s2>Atlanta, GA</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Wang, J S" sort="Wang, J S" uniqKey="Wang J" first="J.-S." last="Wang">J.-S. Wang</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Environmental Health Science, University of Georgia</s1><s2>Athens, GA</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Phillips, T D" sort="Phillips, T D" uniqKey="Phillips T" first="T. D." last="Phillips">T. D. Phillips</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Veterinary Integrative Biosciences, Texas A&M University</s1><s2>College Station, TX</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Williams, J H" sort="Williams, J H" uniqKey="Williams J" first="J. H." last="Williams">J. H. Williams</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>College of Agricultural and Environmental Sciences, University of Georgia</s1><s2>Griffin, GA</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Food additives & contaminants : part A chemistry, analysis, control, exposure & risk assessment</title></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Food additives & contaminants : part A chemistry, analysis, control, exposure & risk assessment</title></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adduct</term><term>Aflatoxin B1</term><term>Albumin</term><term>Association</term><term>Ghana</term><term>Liver</term><term>Virus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Association</term><term>Foie</term><term>Aflatoxine B1</term><term>Virus</term><term>Albumine</term><term>Composé addition</term><term>Ghana</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Association</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We examined the association between certain clinical factors and aflatoxin B<sub>1</sub>-albumin adduct (AF-ALB) levels in HIV-positive people. Plasma samples collected from 314 (155 HIV-positive and 159 HIV-negative) people were tested for AF-ALB levels, viral load, CD4<sub>+</sub> T-cell count, liver function profile, malaria parasitaemia, and hepatitis B and C virus infections. HIV-positive participants were divided into high and low groups based on their median AF-ALB of 0.93 pmol mg<sup>-1</sup> albumin and multivariable logistic and linear regression methods used to assess relationships between clinical conditions and AF-ALB levels. Multivariable logistic regression showed statistically significant increased odds of having higher HIV viral loads (OR=2.84; 95% CI=1.17-7.78) and higher direct bilirubin levels (OR=5.47; 95% CI=1.03-22.85) among HIV-positive participants in the high AF-ALB group. There were also higher levels of total bilirubin and lower levels of albumin in association with high AF-ALB. Thus, aflatoxin exposure may contribute to high viral loads and abnormal liver function in HIV-positive people and so promote disease progression.</div></front></TEI><affiliations><list><country><li>Ghana</li><li>États-Unis</li></country><region><li>Alabama</li><li>Géorgie (États-Unis)</li><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Alabama"><name sortKey="Jolly, P E" sort="Jolly, P E" uniqKey="Jolly P" first="P. E" last="Jolly">P. E. Jolly</name></region><name sortKey="Jiang, Y" sort="Jiang, Y" uniqKey="Jiang Y" first="Y." last="Jiang">Y. Jiang</name><name sortKey="Phillips, T D" sort="Phillips, T D" uniqKey="Phillips T" first="T. D." last="Phillips">T. D. Phillips</name><name sortKey="Shuaib, F M" sort="Shuaib, F M" uniqKey="Shuaib F" first="F. M" last="Shuaib">F. M. Shuaib</name><name sortKey="Stiles, J K" sort="Stiles, J K" uniqKey="Stiles J" first="J. K." last="Stiles">J. K. Stiles</name><name sortKey="Wang, J S" sort="Wang, J S" uniqKey="Wang J" first="J.-S." last="Wang">J.-S. Wang</name><name sortKey="Williams, J H" sort="Williams, J H" uniqKey="Williams J" first="J. H." last="Williams">J. H. Williams</name></country><country name="Ghana"><noRegion><name sortKey="Preko, P" sort="Preko, P" uniqKey="Preko P" first="P." last="Preko">P. Preko</name></noRegion><name sortKey="Baidoo, J" sort="Baidoo, J" uniqKey="Baidoo J" first="J." last="Baidoo">J. Baidoo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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